Isaac Scientific Publishing

Modern Organic Chemistry Research

Synthesis, Characterization, in vitro Antimicrobial, and Anthelmintic Evaluations of N-(4, 6-dimethylpyrimidin-2-yl)-4-((2-hydroxynaphthalen-1-yl) diazenyl) Benzene Sulfonamide and Its Metal (II) Complexes

Download PDF (421.6 KB) PP. 33 - 40 Pub. Date: April 20, 2017

DOI: 10.22606/mocr.2017.22001

Author(s)

  • Jagdish Badgujar
    School of Chemical Sciences, North Maharashtra University, Jalgaon 425001, India
  • Dhananjay More

    School of Chemical Sciences, North Maharashtra University, Jalgaon 425001, India
  • Jyotsna Meshram*
    Department of Chemistry, Rashtrasant Tukadoji Maharaj Nagpur University, Nagpur 440033, India

Abstract

As a part of systematic investigation of biologically active compound, new azo dye ligand N-(4, 6-dimethylpyrimidin-2-yl)-4-((2-hydroxynaphthalen-1-yl) diazenyl) benzene sulfonamide has been synthesized by diazotization of 4-amino-N-(4, 6-dimethylpyrimidin-2-yl) benzenesulfonamide and coupled with coupling compound, naphthalen-2-ol. A new series of Ni (II), Cu (II), and Zn (II) complexes derived from this azo dye ligand (L) were synthesized. The structures of the ligand and metal complexes were confirmed by spectroscopic studies (elemental analysis, IR, 1H NMR and mass spectra). The azo dye and its complexes have been screened for their in vitro antimicrobial activities against some bacterial stains and fungal strains by disc diffusion method. The results showed that, the presence of metal causes more inhibition. The anthelmentic activity of the ligand and its complexes against adult Indian earthworms, Pheretima postuma are also investigated.

Keywords

Azo dye, sulfonamide, metal complexes, antimicrobial activity, anthelmentic activity.

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