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Modern Organic Chemistry Research
MOCR > Volume 4, Number 1, February 2019

The Stability Study of a Novel Phenylpiperazine Derivative

Download PDF  (828.9 KB)PP. 1-12,  Pub. Date:January 29, 2019
DOI: 10.22606/mocr.2019.41001

Author(s)
Monika TARSA1, Małgorzata STAREK2*, Monika DĄBROWSKA2, Marzena BARAN1, Agnieszka CZARNY3, Marek CEGŁA1
Affiliation(s)
1Department of Organic Chemistry; 2Department of Inorganic and Analytical Chemistry, Faculty of Pharmacy, Jagiellonian University Medical College, 9 Medyczna St, 30-688 Krakow, Poland; 3Department of Organic Chemistry, Faculty of Chemistry, Jagiellonian University Medical College, 3 Ingardena St, 30-060 Krakow, Poland
Abstract
N-phenylpiperazine compounds are a very large class of chemicals, and some of them have the ability to cross the blood-brain barrier due to the small size and the lipohilic nature. This group of compounds shows an interesting spectrum of biological activities. The chemical stability of the drugs determines the quality of the drug, affects safety, efficacy and storage conditions. The active compounds have diverse molecular structure and are susceptible to many variable degradation pathways, such as hydrolysis, oxidation, photodegradation, isomerization, elimination, dehydration and interaction with others substances. A hydrolysis degradation process is one of the most common destructive processes for chemical structures. It depends on various conditions e.g. temperature, pH and the chemical properties of a substance. The aims of this investigation were to study the stability testing of 2-[(4-phenylpiperazino)methyl]-2,3-dihydro-5H-[1,3]oxazolo[3,2-a]pyridine-5-one, a new oxazolopyridonyl derivative of phenylpiperazine. A probable pathway of its chemical degradation was designated, based on the kinetic parameters and the identification products by the chromatographic methods.
Keywords
N-phenylpiperazine; stability; spectrophotometry; chromatography
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