Journal of Advances in Molecular Biology

Download PDF (344.3 KB) PP. 105 - 112 Pub. Date: September 1, 2017

DOI: 10.22606/jamb.2017.12003

• Irena Cosic^*
  RMIT University, La Trobe Street, Melbourne, 3000, Victoria, Australia
• Drasko Cosic
  AMALNA Consulting, 46 Second St, Black Rock, 3193, Victoria, Australia
• Katarina Lazar
  AMALNA Consulting, 46 Second St, Black Rock, 3193, Victoria, Australia

It is documented that the large number of mutations within BRCA-1 and BRCA-2 genes are related to development of breast cancer, ovarian cancer, as well as prostate cancer and pancreatic cancer. However, it is not known which mutations are the most critical for formation of these cancers. We have analysed human BRCA-1, BRCA-2 and related RAD51 protein functions and functional mutations using our previously developed Resonant Recognition Model (RRM). The RRM is capable to analyse protein biological functions/interactions, predict bioactive mutations and design de novo bioactive peptides with desired biological function. The most critical mutations for formation of cancer in human BRCA-1, BRCA-2 and RAD51 proteins have been predicted and compared with experimental results. The predicted mutations within 3D structures have been presented and discussed. Such findings can lead to development of much simpler and more relevant tests for genetic predisposition to breast, ovarian, prostate and pancreatic cancers.

Genetic predisposition to cancer; BRCA-1, BRCA-2 and RAD51; resonant recognition model; molecular modelling.

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