Isaac Scientific Publishing


Effects of Neurotransplantation and Electrostimulation of Subthalamic Nucleus on the State of the Catecholaminergic System of Nucleus Caudatus in Rats with Nigrostriatal Failure

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  • Anna Titkova*
    Laboratory of Neurophysiology, Immunology and Biochemistry, Institute of Neurology, Psychiatry and Narcology of NAMS of Ukraine, Ukraine
  • Olga Berchenko
    Laboratory of Neurophysiology, Immunology and Biochemistry, Institute of Neurology, Psychiatry and Narcology of NAMS of Ukraine, Ukraine


The purpose of the research was to study the effects of neurotransplantation of embryonic nervous tissues (ENT) and electrostimulation of subthalamic nucleus (STN) on catecholamine contents in nucleus caudatus in rats with electrolytic lesion of substantia nigra (SNc). The following methods were used: the model of nigrostriatal failure created by electrolytic lesion of SNc in rats; transplantation of rat brain ENT into nucleus caudatus; electrostimulation of STN with low intensity current. Transplantation of ENT into nucleus caudatus contributes to the recovery of movement disorders and dopamine levels in nucleus caudatus disturbed as a result of SNc lesion. Electrostimulation of STN significantly enhances the effect of neurotransplantation and is accompanied with the increase of content and metabolism of dopamine in nucleus caudatus. Electrostimulation of STN with low intensity current creates additional conditions for compensation of dopamine deficiency in nucleus caudatus after neurotransplantation in rats with nigrostriatal failure.


Movement disorders, neurotransplantation of embryonic tissue, electrostimulation of STN, nucleus caudatus, catecholamines.


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