Isaac Scientific Publishing


Sense Oligodeoxynucleotides to GluN1 Subunit of NMDARs Improve Long-Term Potentiation Development and Protect Synaptic Activity in Anoxic Conditions

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  • Anatoly A. Mokrushin*
    I.P. Pavlov Institute of Physiology, Russian Academy Science, Saint-Petersburg, Russia


Modifications of N-methyl-D-aspartate receptors (NMDARs) have been implicated in synaptic plasticity and learning in normal and pathological conditions. We studied the efficiency of synaptic plasticity - the development of the long-term potentiation/depression (LTP/LTD) in olfactory cortex slices, modifying the GluN1 subunit of NMDARs with sense or antisense oligodeoxynucleotides (ODNs). Treatment of slices with sense ODNs to GluN1 subunit enhanced LTP and acted as nootrop - piracetam. In ischemia-like conditions (severe 10 min anoxia), treatment of slices with sense ODNs protected synaptic activity and promoted the development of LTP in contrast to complete inhibition of the activity in control conditions. In practical implications such directed up-regulation of NMDARs may be taken into attention for adjusting their activity as specific target for clinic.


Synaptic plasticity, field potentials, GluN1 subunit NMDAR


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